{"id":9730,"date":"2026-09-01T15:20:26","date_gmt":"2026-09-01T13:20:26","guid":{"rendered":"https:\/\/jacked.sk\/?post_type=product&#038;p=9730"},"modified":"2026-09-01T15:21:35","modified_gmt":"2026-09-01T13:21:35","slug":"nad-500-mg","status":"publish","type":"product","link":"https:\/\/jacked.sk\/en\/obchod\/nad-500-mg\/","title":{"rendered":"NAD+ 500mg"},"content":{"rendered":"<p><strong>\u26a0\ufe0f Notice:<\/strong> research compound for laboratory use only. Not for human or veterinary consumption, diagnosis or treatment. Sold to adults 18+ only.<\/p>\n<p>NAD+ is neither a peptide nor an experimental molecule \u2014 it is one of the basic building blocks of metabolism. What makes it interesting for research is that its availability inside the cell shifts over a lifetime: by middle age it has fallen to roughly half, a decline that overlaps with deteriorating mitochondrial function and an accumulation of unrepaired DNA damage.<\/p>\n<h3>Where NAD+ comes into play<\/h3>\n<ul>\n<li><strong>Cellular respiration<\/strong> \u2014 it accepts electrons in glycolysis, the Krebs cycle and beta-oxidation, then as NADH hands them to the respiratory chain for ATP production.<\/li>\n<li><strong>Sirtuins (SIRT1\u20137)<\/strong> \u2014 NAD+-dependent deacetylases governing gene expression, mitochondrial biogenesis, DNA repair and stress responses. Without NAD+ they simply do not work.<\/li>\n<li><strong>PARP enzymes<\/strong> \u2014 they consume NAD+ when detecting DNA breaks; in oxidative and UV damage models that consumption is a research topic in its own right.<\/li>\n<li><strong>CD38 and SARM1<\/strong> \u2014 enzymes that degrade NAD+ instead; studied in the context of inflammation and axonal degeneration.<\/li>\n<\/ul>\n<h3>Direct NAD+ versus the precursors NMN and NR<\/h3>\n<p>Precursors only reach NAD+ through enzymatic conversion along the salvage pathway (NMNAT and NRK respectively). For <strong>in vitro<\/strong> work, direct NAD+ is therefore the more precise tool \u2014 you set the concentration in the medium yourself, with no variable in the form of conversion efficiency. For <strong>in vivo<\/strong> models researchers generally reach for precursors instead, for their better bioavailability.<\/p>\n<h3>Specifications<\/h3>\n<table>\n<tbody>\n<tr>\n<td>Name<\/td>\n<td>Nicotinamide adenine dinucleotide (oxidised form)<\/td>\n<\/tr>\n<tr>\n<td>CAS<\/td>\n<td>53-84-9<\/td>\n<\/tr>\n<tr>\n<td>Formula<\/td>\n<td>C\u2082\u2081H\u2082\u2087N\u2087O\u2081\u2084P\u2082 (663.43 Da)<\/td>\n<\/tr>\n<tr>\n<td>Content<\/td>\n<td>500 mg \/ vial<\/td>\n<\/tr>\n<tr>\n<td>Form<\/td>\n<td>Lyophilised powder<\/td>\n<\/tr>\n<tr>\n<td>Purity<\/td>\n<td>\u2265 98% (HPLC)<\/td>\n<\/tr>\n<tr>\n<td>Intended use<\/td>\n<td>Preclinical and laboratory research, 18+<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>Storage and reconstitution<\/h3>\n<p>Keep the lyophilisate at \u221220 \u00b0C, protected from light and moisture. Dissolve in deionised water or PBS at pH 7.4 \u2014 NAD+ is prone to hydrolysis at higher pH, so do not take it above 7.4. Store the solution at 2\u20138 \u00b0C and use within 7 days; for longer storage, \u221280 \u00b0C.<\/p>\n<p><em>NAD+ in this form is not a medicine, a food supplement or a cosmetic product, and is not approved by any regulatory body for human use. The seller accepts no liability for use contrary to these terms.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>NAD+ (nicotinamide adenine dinucleotide) is the coenzyme without which cellular respiration cannot proceed in any living organism. It also serves as the substrate for sirtuins and PARP enzymes \u2014 and because its levels fall sharply with age, it is one of the most heavily studied molecules in the biology of ageing.<\/p>\n<ul>\n<li>Purity <strong>\u2265 98%<\/strong> \u2013 HPLC verified, COA on request<\/li>\n<li>Lyophilised powder, store at \u221220 \u00b0C<\/li>\n<li>Dispatch within 48 h<\/li>\n<\/ul>\n","protected":false},"featured_media":9733,"template":"","meta":[],"product_brand":[],"product_cat":[137],"product_tag":[],"class_list":["post-9730","product","type-product","status-publish","has-post-thumbnail","product_cat-recovery-rehabilitation","first","instock","sale","taxable","shipping-taxable","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>NAD+ 500mg - jacked.sk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/jacked.sk\/en\/obchod\/nad-500-mg\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NAD+ 500mg - jacked.sk\" \/>\n<meta property=\"og:description\" content=\"NAD+ (nicotinamide adenine dinucleotide) is the coenzyme without which cellular respiration cannot proceed in any living organism. It also serves as the substrate for sirtuins and PARP enzymes \u2014 and because its levels fall sharply with age, it is one of the most heavily studied molecules in the biology of ageing.   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It also serves as the substrate for sirtuins and PARP enzymes \u2014 and because its levels fall sharply with age, it is one of the most heavily studied molecules in the biology of ageing.   Purity \u2265 98% \u2013 HPLC verified, COA on request  Lyophilised powder, store at \u221220 \u00b0C  Dispatch within 48 h","og_url":"https:\/\/jacked.sk\/en\/obchod\/nad-500-mg\/","og_site_name":"jacked.sk","article_publisher":"https:\/\/www.facebook.com\/jacked.sk","article_modified_time":"2026-09-01T13:21:35+00:00","og_image":[{"width":1200,"height":1311,"url":"https:\/\/jacked.sk\/wp-content\/uploads\/nad-plus-koenzym-vial-jacked.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/jacked.sk\/en\/obchod\/nad-500-mg\/","url":"https:\/\/jacked.sk\/en\/obchod\/nad-500-mg\/","name":"NAD+ 500mg - jacked.sk","isPartOf":{"@id":"https:\/\/jacked.sk\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/jacked.sk\/en\/obchod\/nad-500-mg\/#primaryimage"},"image":{"@id":"https:\/\/jacked.sk\/en\/obchod\/nad-500-mg\/#primaryimage"},"thumbnailUrl":"https:\/\/jacked.sk\/wp-content\/uploads\/nad-plus-koenzym-vial-jacked.jpg","datePublished":"2026-09-01T13:20:26+00:00","dateModified":"2026-09-01T13:21:35+00:00","breadcrumb":{"@id":"https:\/\/jacked.sk\/en\/obchod\/nad-500-mg\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/jacked.sk\/en\/obchod\/nad-500-mg\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/jacked.sk\/en\/obchod\/nad-500-mg\/#primaryimage","url":"https:\/\/jacked.sk\/wp-content\/uploads\/nad-plus-koenzym-vial-jacked.jpg","contentUrl":"https:\/\/jacked.sk\/wp-content\/uploads\/nad-plus-koenzym-vial-jacked.jpg","width":1200,"height":1311,"caption":"NAD+ \u2013 lyofilizovan\u00fd koenz\u00fdm vo viale pre laborat\u00f3rny v\u00fdskum"},{"@type":"BreadcrumbList","@id":"https:\/\/jacked.sk\/en\/obchod\/nad-500-mg\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Domovsk\u00e1 str\u00e1nka","item":"https:\/\/jacked.sk\/en\/"},{"@type":"ListItem","position":2,"name":"Shop","item":"https:\/\/jacked.sk\/en\/shop-peptides\/"},{"@type":"ListItem","position":3,"name":"NAD+ 500mg"}]},{"@type":"WebSite","@id":"https:\/\/jacked.sk\/en\/#website","url":"https:\/\/jacked.sk\/en\/","name":"jacked.sk","description":"Jacked Peptidy Najvy\u0161\u0161ej Kvality","publisher":{"@id":"https:\/\/jacked.sk\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/jacked.sk\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/jacked.sk\/en\/#organization","name":"Jacked","url":"https:\/\/jacked.sk\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/jacked.sk\/en\/#\/schema\/logo\/image\/","url":"https:\/\/jacked.sk\/wp-content\/uploads\/Jacked.png","contentUrl":"https:\/\/jacked.sk\/wp-content\/uploads\/Jacked.png","width":1481,"height":3523,"caption":"Jacked"},"image":{"@id":"https:\/\/jacked.sk\/en\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/jacked.sk"]}]}},"_links":{"self":[{"href":"https:\/\/jacked.sk\/en\/wp-json\/wp\/v2\/product\/9730","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jacked.sk\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/jacked.sk\/en\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/jacked.sk\/en\/wp-json\/wp\/v2\/media\/9733"}],"wp:attachment":[{"href":"https:\/\/jacked.sk\/en\/wp-json\/wp\/v2\/media?parent=9730"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/jacked.sk\/en\/wp-json\/wp\/v2\/product_brand?post=9730"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/jacked.sk\/en\/wp-json\/wp\/v2\/product_cat?post=9730"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/jacked.sk\/en\/wp-json\/wp\/v2\/product_tag?post=9730"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}